A tri-compound formula comprising Ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model
This study, for the first time, demonstrated that the topical application of GTI alleviates symptoms of AD without overt toxicity in a calcipotriol-induced AD mouse model. The anti-AD effects of GTI are associated with the suppression of allergic reactions, reduction of hyperactive immune responses, improvement of skin barrier function, and inhibition of MAPK activation. These findings suggest that GTI has the potential to be developed into a safe and effective treatment for AD.
Authors
- Xiu‐Qiong Fu (ORCID: https://orcid.org/0000-0002-1458-9720)
- Zhi‐Ling Yu (ORCID: https://orcid.org/0000-0002-2979-9608)
- Jing‐Xuan Bai (ORCID: https://orcid.org/0000-0002-1766-7296)
- Lily Wong (ORCID: https://orcid.org/0000-0003-0569-3398)
- Jia‐Ying Wu (ORCID: https://orcid.org/0000-0003-0805-1163)
- Amy Sze-Man Li
- Li Wang (ORCID: https://orcid.org/0000-0003-0510-7985)
- Xiaoqi Wang
- Yingjie Chen (ORCID: https://orcid.org/0000-0002-4059-7847)
- Xiaoyun Fan
- Ying Wu (ORCID: https://orcid.org/0000-0002-5090-9656)
Institutions
- Hong Kong Baptist University (HK)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.phymed.2025.156737
- Citations
- 7
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 14.03