Efficacy of Neoadjuvant Therapy and the Prognostic Significance of Serum Carcinoembryonic Antigen Level in Patients with Localized Pancreatic Adenocarcinoma with Non-elevated Carbohydrate Antigen 19-9 Levels
NAT followed by surgical resection improves outcomes in patients with PDAC with non-elevated CA 19-9 levels. Elevated CEA levels were associated with adverse prognostic effects on both OS and RFS. These findings support the need for further evaluation of patients with non-elevated CA 19-9 levels and serum CEA levels in prospective settings.
Authors
- Tingbo Liang (ORCID: https://orcid.org/0000-0003-3262-2587)
- Motaz Qadan (ORCID: https://orcid.org/0000-0001-6951-8308)
- Marwa F. Mohamed (ORCID: https://orcid.org/0000-0002-7142-1828)
- Qian Zhu (ORCID: https://orcid.org/0009-0009-6511-2891)
- Keith D. Lillemoe (ORCID: https://orcid.org/0000-0003-4283-8437)
- Carlos Fernandez del-Castillo
- Louisa Bolm (ORCID: https://orcid.org/0000-0002-1612-1857)
- Zhi‐Yong Yang
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Xiang Li (ORCID: https://orcid.org/0000-0002-4675-5367)
- Yiwen Chen (ORCID: https://orcid.org/0000-0002-9008-8346)
- Xueli Bai (ORCID: https://orcid.org/0000-0001-6005-8384)
- Guoliang Qiao
Institutions
- Wuhan University (CN)
- Massachusetts General Hospital (US)
- University Hospital Schleswig-Holstein (DE)
- Zhongnan Hospital of Wuhan University (CN)
- Blood Center of Zhejiang Province (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- University of Lübeck (DE)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1097/sla.0000000000006719
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00