Recent Advances in Mammalian Olfactory Receptor Function and Structure
ABSTRACT Olfaction plays a fundamental role in survival and socialization of human beings, and its dysfunction not only includes deficits in smell but also contributes to the progression of various diseases. This review explores the role of mammalian olfactory receptors in odor perception and signaling within the olfactory system, their expression outside olfactory tissues, and recent structural discoveries. The involvement of olfactory receptors is investigated in diseases such as Alzheimer's and immune disorders, highlighting their potential as therapeutic targets. The olfactory activation mechanisms are summarized, offering a valuable reference for disease research and drug development targeting olfactory receptors, with the goal of advancing treatments for olfactory‐related diseases.
Authors
- Ji‐Tseng Fang (ORCID: https://orcid.org/0000-0003-4977-5360)
- Jiali Wei
- Wei Yan (ORCID: https://orcid.org/0000-0002-1123-0835)
- Changling Xu
- Bin Yan (ORCID: https://orcid.org/0000-0001-5426-6179)
- Fan Wu (ORCID: https://orcid.org/0009-0008-6936-0457)
- Kexin Wang (ORCID: https://orcid.org/0000-0003-1282-6259)
- Hongxi Qin
- Yaping He (ORCID: https://orcid.org/0000-0002-5378-3809)
- Hong Fu
Institutions
- University of Electronic Science and Technology of China (CN)
- Medical University of South Carolina (US)
- Sichuan University (CN)
- Hainan General Hospital (CN)
- Hainan Medical College Hospital (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Sensory Neuroscience
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/sen2.70000
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province