Cord blood metabolomic profiling in high risk newborns born to diabetic, obese, and overweight mothers: preliminary report
Estrogen metabolites from the 16- and 2-pathways may indicate metabolic risk, with increased downstream flux under diabetic conditions. Accelerated bile acid synthesis may alter fetal metabolic programming, since bile acids play crucial roles in cellular energy regulation and signaling. Elevated pantothenic acid, essential for the production of coenzyme-A, suggests significant alterations in carbohydrate, protein, and fat metabolism. High serum DGLA levels emerge as a potential biomarker for metabolic abnormalities. Increased plasma kynurenines could predict cardiovascular risks. Larger targeted studies are required to validate these metabolic profiles and pathways.
Authors
- Ufuk Bozkurt Obuz (ORCID: https://orcid.org/0000-0003-4544-9285)
- Müge Çınar (ORCID: https://orcid.org/0000-0003-4309-2331)
- Mustafa Çelebi̇er (ORCID: https://orcid.org/0000-0001-7712-5512)
- İncilay Lay (ORCID: https://orcid.org/0000-0002-1466-5746)
- Özlem Ünal Uzun (ORCID: https://orcid.org/0000-0001-7937-7721)
- Ayla Günlemez (ORCID: https://orcid.org/0000-0003-1492-3861)
- Duygu Eneş (ORCID: https://orcid.org/0000-0002-8908-3177)
- Büşra Uçar (ORCID: https://orcid.org/0009-0007-0416-1185)
- Ali Duranoğlu (ORCID: https://orcid.org/0000-0002-4299-6569)
Institutions
- Başkent University (TR)
- Hacettepe University Hospital (TR)
- Kocaeli Üniversitesi (TR)
- Hacettepe University (TR)
- Sinop University (TR)
Publication Details
- Journal
- Journal of Pediatric Endocrinology and Metabolism
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1515/jpem-2024-0605
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33