Plant-derived alginate cryogel: a promising biomaterial for wound healing and hemostatic applications

Abstract This study aims to synthesize and characterize an innovative, antibacterial, biocompatible alginate containing PHEMA based cryogel(A-PHEMA) integrated with tea tree oil (TTO) for wound healing and hemostatic applications. Alginate, a natural polysaccharide known for its biocompatibility and hemostatic properties, was expected to enhance the structural properties of the cryogel. Cryogels with increased concentrations of TTO were selected through an extensive analytical validation process, as TTO is renowned for its antimicrobial and wound-healing properties. The results demonstrate remarkable antibacterial activity, especially in the A-100 T variant. In vitro evaluations highlight significant antibacterial activity, preserved cell viability, notable wound healing capabilities, and rapid hemostasis. In addition to the highlighted antibacterial activity, cryogels exhibit significant hemostatic properties. Rapid hemostasis, a critical element in wound management, underscores the versatile nature of the A-100 T variant. The integration of alginate and TTO in cryogels offers a versatile biomaterial for acute wound scenarios. The success of the A-100 T variant underscores its potential as a rapid hemostatic agent, pointing to a promising future in emergency medical care.