Establishing the Median and 95% Effective Doses of Oliceridine for Immediate Post-Surgical Analgesia Following Laparoscopic Cholecystectomy: A Double-Blind, Sequential Dose-Finding Study
Our findings establish that for early postoperative pain management, oliceridine demonstrates optimal therapeutic efficacy at an ED50 of 18.45 ug/kg, with the ED95 determined to be 22.39 ug/kg.
Authors
- Guizhen Xu
- Jian Chen (ORCID: https://orcid.org/0000-0002-1999-1137)
- Xueping Li (ORCID: https://orcid.org/0000-0003-4217-3949)
- Zhijian Zhang (ORCID: https://orcid.org/0000-0001-5549-1546)
- Yujiao Wei
- Huichang Yan (ORCID: https://orcid.org/0000-0002-8357-2332)
- Q. G. Wen (ORCID: https://orcid.org/0000-0002-5556-9419)
- Huiling Xiao
- Bin-Bin Xu
- Xianghua Cao
Institutions
- Tung Wah Hospital (CN)
- Key Laboratory of Guangdong Province (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s505079
- Citations
- 3
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 6.02