In silico genomic insights into bacteriophages infecting ESBL-producing Escherichia coli from human, animal, and environmental sources
This is the first study in Nigeria to characterize phages in ESBL-EC isolates at the One Health interface. The presence of intact phages in humans, animals, and the environment underscores the complex interactions shaping phage ecology. The discovery of ARGs, virulence genes, and heavy metal resistance within prophages suggests a potential role in AMR dissemination. Future research should focus on elucidating mechanisms of ARG transfer mediated by phages in One Health settings.
Authors
- René S. Hendriksen (ORCID: https://orcid.org/0000-0003-2934-8214)
- Opeyemi U. Lawal (ORCID: https://orcid.org/0000-0003-2352-2832)
- Mabel Kamweli Aworh (ORCID: https://orcid.org/0000-0003-4213-6929)
- Beverly Egyir (ORCID: https://orcid.org/0000-0002-5032-8739)
Institutions
- Noguchi Memorial Institute for Medical Research (GH)
- CNR de la Résistance aux Antibiotiques (FR)
- University of Windsor (CA)
- University of Guelph (CA)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12866-025-03913-9
- Citations
- 1
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- University of Ghana
- Noguchi Memorial Institute for Medical Research, University of Ghana