Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
These results confirm that Brosimine B exhibits hormetic neuroprotective effects within a well-defined concentration window, supporting its potential as a therapeutic agent for oxidative stress-related retinal damage. The study highlights the value of computational modeling in optimizing dose-response analyses, offering a framework for refining natural product therapies and predicting toxicological thresholds in pharmacological applications.
Authors
- Antônio Pereira Júnior (ORCID: https://orcid.org/0000-0001-6241-985X)
- Nádia Miléo Garcês de Couto (ORCID: https://orcid.org/0000-0003-0346-5615)
- Susanne Suely Santos da Fonseca (ORCID: https://orcid.org/0000-0003-3002-919X)
- Gisele Priscila Soares de Aguiar (ORCID: https://orcid.org/0000-0003-4778-2874)
- Elizabeth Sumi Yamada
- Natacha Medeiros de Souza Port’s (ORCID: https://orcid.org/0000-0002-0927-2315)
- Carlomagno Pacheco Bahia (ORCID: https://orcid.org/0000-0003-3794-4710)
- Mara S.P. Arruda (ORCID: https://orcid.org/0000-0003-1595-6876)
- André Salim Khayat
- Chubert Bernardo Castro de Sena (ORCID: https://orcid.org/0000-0002-2328-9885)
- W.B.S. Pinheiro
- Edmar Tavares da Costa
- Eliã P. Botelho
Institutions
- Instituto Federal de Educação, Ciência e Tecnologia do Pará (BR)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fphar.2025.1558726
- Citations
- 4
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Pará