Antipsychotic therapy and suicide risk in patients with treatment-resistant depression: target trial emulation framework study
Antipsychotic augmentation was not associated with reduced risk of suicide-related outcomes when time-lag bias was addressed; however, it was associated with increased all-cause mortality. These findings do not support the use of antipsychotic augmentation in patients with treatment-resistant depression.
Authors
- Zee Wan Wong (ORCID: https://orcid.org/0000-0002-3055-2119)
- Edward Chia‐Cheng Lai (ORCID: https://orcid.org/0000-0002-5852-7652)
- Daniel Hsiang‐Te Tsai (ORCID: https://orcid.org/0000-0003-2841-0338)
- Chin‐Yao Shen (ORCID: https://orcid.org/0000-0002-8885-6406)
- Shih‐Chieh Shao (ORCID: https://orcid.org/0000-0003-4867-6686)
- Avery Shuei‐He Yang (ORCID: https://orcid.org/0000-0002-1674-0148)
- Michael Chun‐Yuan Cheng (ORCID: https://orcid.org/0000-0002-8640-3593)
- Albert Tzu-Ming Chuang
Institutions
- Keelung Chang Gung Memorial Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1192/bjp.2024.283
- Citations
- 2
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 2.79