The treatment with soluble guanylate cyclase stimulator BAY41-8543 prevents malignant hypertension and associated organ damage
The treatment with NO-independent sGC stimulator displayed marked protective actions on the course of malignant hypertension-related mortality and malignant hypertension-related cardiac damage. This suggests that application of sGC stimulator could be a promising therapeutic means for the treatment of malignant hypertension.
Authors
- Soňa Kikerlová
- Hana Malínská
- Martina Hüttl (ORCID: https://orcid.org/0000-0002-2484-3630)
- Michal Šnorek (ORCID: https://orcid.org/0009-0004-2593-7585)
- Lenka Hošková (ORCID: https://orcid.org/0000-0003-4616-0862)
- Zuzana Honetschlägerová (ORCID: https://orcid.org/0000-0002-8369-4428)
- Luděk Červenka (ORCID: https://orcid.org/0000-0002-2256-9631)
- Petr Kala (ORCID: https://orcid.org/0000-0001-5626-7706)
- Matúš Miklovič (ORCID: https://orcid.org/0000-0003-0427-2583)
- Vojtěch Melenovský (ORCID: https://orcid.org/0000-0001-8921-7078)
- Petra Škaroupková
- Olga Gawryś (ORCID: https://orcid.org/0000-0002-4397-3991)
- Peter Sandner (ORCID: https://orcid.org/0000-0003-2977-7553)
- Miloš Táborský (ORCID: https://orcid.org/0000-0002-5036-2347)
- Miklós Molnár (ORCID: https://orcid.org/0000-0001-9231-782X)
- Janusz Sadowski (ORCID: https://orcid.org/0000-0002-9701-5334)
- Zdeňka Vaňourková
Institutions
- Charles University (CZ)
- Medizinische Hochschule Hannover (DE)
- University Hospital Olomouc (CZ)
- Nemocnice České Budějovice (CZ)
- Institute of Clinical and Experimental Medicine (CZ)
- Bayer (Germany) (DE)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1097/hjh.0000000000004009
- Citations
- 2
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78