Palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates: access to tetrahydropyridazines bearing allenes
A highly efficient palladium-catalysed alleneamination of γ,δ-unsaturated hydrazones with propargylic acetates has been developed. This novel method was used to synthesize tetrahydropyridazines bearing allene derivatives, and did so in moderate to good yields. This protocol features a simple catalytic system, broad substrate scope, easy scale-up, and versatile transformations.
Authors
- Weiming Hu (ORCID: https://orcid.org/0000-0002-0157-1089)
- Shuaijie Wu
- Youzhou He (ORCID: https://orcid.org/0000-0002-7586-2321)
- Shiji Xu
- Chao‐Guo Yan (ORCID: https://orcid.org/0000-0002-2777-9582)
- Lei Wang (ORCID: https://orcid.org/0000-0002-8792-0234)
- Wei Jiang (ORCID: https://orcid.org/0000-0003-1067-0406)
- Jing Sun (ORCID: https://orcid.org/0000-0002-8341-7367)
Institutions
- Shanghai Ocean University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4cc06716a
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province