Mechanochemical synthesis, simultaneous double cycloaddition reactions of bisnitrones and potential anticancer activities of the bis cycloadducts

Solid phase synthesis of bisnitrones and cycloaddition reactions  of some bisnitrones using mechanochemical procedure has been reported. Change in reaction rate and yields of the bisnitrones as well as bis cycloadducts is the key factors which is highly encouraging comparing with microwave and coventional cycloaddition procedures. This study reports synthesis of terephthalaldehyde and glyoxal derived bis-nitrones and their cycloaddition reactions with activated alkenes and electron deficient alkynes along with significant anticancer activities of few bis-cycloadducts.