TRIM22 governs tumorigenesis and protects against endometrial cancer-associated cachexia by inhibiting inflammatory response and adipose thermogenic activity
Our data reveals that TRIM22-EC-IL-6-cachexia cross-communication has important clinical relevance and that the use of combined therapy holds great promise for enhancing the efficacy of anti-ECs. (Fig. graphical abstract).
Authors
- Gang Wei (ORCID: https://orcid.org/0000-0002-8051-5260)
- Peifang Chen
- Quanrong Li
- D.F. Chen
- Weichao Dai (ORCID: https://orcid.org/0000-0001-6114-1104)
- Zhiqun Zheng (ORCID: https://orcid.org/0000-0002-2309-7162)
- Min Wu (ORCID: https://orcid.org/0000-0002-0668-8315)
- Ping Zhang (ORCID: https://orcid.org/0000-0001-9163-6191)
- Xiaoyan Lin (ORCID: https://orcid.org/0000-0003-0759-3913)
- Xiushan Feng
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s40170-025-00386-2
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China