Intensity-modulated proton therapy for hippocampal-sparing prophylactic cranial irradiation: a planning comparison with photon therapy
Compared with photon plans, proton plans significantly reduce the dose to the hippocampus, lenses, eyeballs and parotids in hippocampal-sparing PCI. Compared to IMPT plans with coplanar beams, IMPT plans with non-coplanar beams have shown dosimetric advantages in eyeballs and lenses, with no benefit for dose sparing in the hippocampus.
Authors
- Tao Sun
- Guifang Zhang (ORCID: https://orcid.org/0000-0002-9690-7226)
- Yong Yin (ORCID: https://orcid.org/0000-0003-1090-4313)
- Xiaoyan Yin (ORCID: https://orcid.org/0000-0001-5103-5500)
- Xiutong Lin
Institutions
- Second Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12885-025-14039-6
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China