Dual-effect of size/polymorph to enhance itraconazole bioavailability by freeze-dissolving crystallization
ITZ amorphous micropowder was prepared via FDT. Its dissolution performance was improved due to the reduction of particle size and amorphous form; and at the same time, the particle size fulfills criteria for dry powder inhalants.
Authors
- Zhenguo Gao (ORCID: https://orcid.org/0000-0002-5953-1514)
- Junbo Gong (ORCID: https://orcid.org/0000-0002-3376-3296)
- Yuxin Zhang (ORCID: https://orcid.org/0009-0004-6159-9309)
- Guo Shengzheng
Institutions
- Tianjin University (CN)
- Unité Matériaux et Transformations (FR)
- State Key Laboratory of Chemical Engineering (CN)
Publication Details
- Journal
- CrystEngComm
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ce00150a
- Primary Topic
- Crystallization and Solubility Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00