Design and synthesis of thiadiazoles as anticancer, apoptotic, and VEGFR-2 inhibitors
Thiadiazole-based derivatives, particularly compound <b>13b</b>, exhibit potent VEGFR-2 inhibition, anti-proliferative effects, apoptosis induction, and anti-migratory activity, supporting their potential as promising anticancer agents.
Authors
- Aly F. Mohamed (ORCID: https://orcid.org/0000-0002-0863-9496)
- Ibrahim H. Eissa (ORCID: https://orcid.org/0000-0002-6955-2263)
- Bshra Ali A. Alsfouk (ORCID: https://orcid.org/0000-0001-6489-6035)
- Walid E. Elgammal (ORCID: https://orcid.org/0000-0002-5982-5635)
- Mohammed A. Dahab (ORCID: https://orcid.org/0000-0002-2016-0728)
- Hazem Elkady (ORCID: https://orcid.org/0000-0003-0893-6703)
- Eslam B. Elkaeed (ORCID: https://orcid.org/0000-0002-2546-8035)
- Hazem A. Mahdy
- Ahmed M. Metwaly (ORCID: https://orcid.org/0000-0001-8566-1980)
- Ahmed Nofal
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Al-Azhar University (ID)
- Almaarefa University
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1080/17568919.2025.2485863
- Citations
- 2
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Princess Nourah Bint Abdulrahman University