An integrated approach to the treatment of infectious lesions of the upper respiratory tract in pediatric practice

Introduction . The article substantiates a comprehensive bioregulatory approach to the treatment and immunorehabilitation of infectious respiratory diseases of the upper respiratory tract in pediatric practice. Aim . To study the efficacy and tolerability of a bioregulatory drug in the complex treatment of children with infectious lesions of the upper respiratory tract. Materials and methods . A prospective single-center study was conducted, 63 children: the main group of 32 children, the bioregulatory drug Tonsilgon® N 14 days was included in the complex of generally accepted therapy; 31 – the control group, only a complex of generally accepted therapy providing an anti-inflammatory effect was carried out. The age of children was 3–5 (4.3 ± 0.37) and 6–12 (9.2 ± 1.48) years in equal numbers by gender. Verification of the pathogen was carried out upon admission: in the main group, group A β-hemolytic streptococcus was detected in 7 (21.87%) patients, in the control group – in 6 (19.35%) patients; In the main group, Ig to Chlamydophila pneumoniae and Mycoplasma pneumoniae were in 9 (28.12%) patients, in the control group – 8 (25.8%), systemic antimicrobial therapy was prescribed. Results . In the main group, on the 3rd day of examination, the treatment was assessed as highly effective in 21 (65.62%), effective in 10 (31.25%), and moderately effective in 1 (3.12%). On average, the effectiveness score for the group was 2.61 ± 0.14 points. Discussion. The broad spectrum of action, due to the diverse composition of the phytoimmunomodulator, has a stimulating effect on the activation of phagocytosis of macrophages and granulocytes, accelerating the elimination of pathogens, which is consistent with our data and with literature data. Conclusions . An integrated approach to the treatment of inflammatory diseases of the oral cavity in children with the inclusion of a bioregulatory drug has a beneficial effect on the course of the inflammatory process in the oropharynx and stimulates the body’s resistance.