Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in <i>Drosophila</i>
Disruption of aryl hydrocarbon receptor (AhR) signaling and aberrant tryptophan metabolism contribute to aging and age-related disorders, but the underlying molecular mechanisms are largely unknown. Using multiomics analyses combined with biochemical assays, this study reveals that AhR activation by indole acetic acid (IAA) effectively extends the lifespan accompanied by improved healthy aging in <i>Drosophila</i> via the AhR-Sirt2 pathway.
Authors
- Qingwei Xiang (ORCID: https://orcid.org/0000-0002-8661-4796)
- Lijun Liu (ORCID: https://orcid.org/0000-0002-6212-3036)
- Hehua Lei (ORCID: https://orcid.org/0000-0001-5088-376X)
- Yu‐Feng Wang (ORCID: https://orcid.org/0000-0002-1823-373X)
- Limin Zhang (ORCID: https://orcid.org/0000-0001-5689-948X)
- Cui Zhang (ORCID: https://orcid.org/0000-0002-6119-5572)
- Zheng Cao (ORCID: https://orcid.org/0000-0002-0670-0484)
- Xinzhi Li (ORCID: https://orcid.org/0009-0009-4429-8228)
- Yan He (ORCID: https://orcid.org/0000-0003-0307-2651)
- Huabao Zhang
- Gang Chen (ORCID: https://orcid.org/0000-0001-9428-6545)
Institutions
- Macau University of Science and Technology (MO)
- Chinese Academy of Sciences (CN)
- Hubei University of Chinese Medicine (CN)
- Central China Normal University (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Wuhan Institute of Physics and Mathematics (CN)
- Quality Research (US)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1128/msystems.01665-24
- Citations
- 4
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 3.81
Funders
- National Natural Science Foundation of China