The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks
Together, our findings shed the light on CBP as a key participant in the ATM activation pathway and in the subsequent repair of DNA double-strand breaks, which may serve as a potential target to modulate the cellular response to DNA damaging agents in cancer.
Authors
- Wael Mansour (ORCID: https://orcid.org/0000-0003-0641-2885)
- Lama Lozon (ORCID: https://orcid.org/0000-0003-2375-6401)
- Raafat El‐Awady (ORCID: https://orcid.org/0000-0002-7046-8587)
- Wafaa S. Ramadan (ORCID: https://orcid.org/0000-0002-7334-3093)
- Samrein B. M. Ahmed (ORCID: https://orcid.org/0000-0001-9773-645X)
- Soraya Mouffak
- Timo Gemoll (ORCID: https://orcid.org/0000-0001-7400-5240)
- Iman M. Talaat (ORCID: https://orcid.org/0000-0002-5259-327X)
Institutions
- Universität Hamburg (DE)
- University of Sharjah (AE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- University Cancer Center Hamburg (DE)
- Sheffield Hallam University (GB)
- University of Lübeck (DE)
Publication Details
- Journal
- Genome biology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s13059-025-03528-3
- Citations
- 3
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.42