The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Valency and apparent affinity affect brain uptake in a dose-dependent manner such that: brain uptake was affected more by apparent affinity at the low dose and by valency at the high dose. Thus, when designing constructs for TfR-mediated brain delivery, the application, and consequently the dose, are critical to consider.
Authors
- Karl Andersson (ORCID: https://orcid.org/0000-0001-9141-9242)
- Stina Syvänen (ORCID: https://orcid.org/0000-0002-8196-4041)
- S. Gojendra Singh (ORCID: https://orcid.org/0009-0004-0779-8067)
- Gillian Bonvicini
- Lisa Sandersjöö (ORCID: https://orcid.org/0000-0001-9504-4054)
- Dag Sehlin (ORCID: https://orcid.org/0000-0002-9430-3859)
Institutions
- Uppsala University (SE)
- BioArctic Neuroscience (Sweden) (SE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12987-025-00643-y
- Citations
- 8
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 10.88
Funders
- Stiftelsen för Gamla Tjänarinnor
- European Commission
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Uppsala Universitet
- Alzheimerfonden
- Science for Life Laboratory