Local therapy for the treatment of paediatric respiratory diseases

The problem of determining the tactics of prescribing topical therapy in respiratory pathology remains relevant in pediatric practice. Local therapy is one of the components of complex treatment of respiratory diseases of upper respiratory tract, ENT organs, however, in the presence of appropriate indications according to the current federal recommendations for the appointment of antibacterial drugs of systemic action can not replace them. The article presents a modern review of scientific literature data on the role of topical drugs in respiratory diseases. Numerous clinical and experimental studies confirm the effectiveness of topical preparation benzydamine, which has a unique combined action, simultaneously influencing various pathogenetic links of inflammation. Benzydamine exhibits antiseptic and anti-inflammatory properties, effectively inhibiting the growth of both Gram-positive and Gram-negative bacteria, as well as some types of fungi, demonstrating resistance to the mechanisms of antibacterial resistance. The key advantage of benzydamine is its ability to penetrate into the focus of inflammation, reaching the necessary therapeutic concentrations. The mechanism of this action is associated with modulation of the activity of various inflammatory mediators such as cytokines and prostaglandins, resulting in a reduction of the inflammatory response. Moreover, benzydamine has immunomodulatory properties, stimulating local immunity and enhancing the activity of local immune cells. This contributes to faster and more effective elimination of the infectious agent and accelerated repair of damaged tissues. Prospective results and detailed evaluation of clinical efficacy of benzydamine, which has a complex of anti-inflammatory properties, were the basis for recommending it as a safe and effective topical drug in the treatment of infectious and inflammatory diseases of the respiratory tract, ENT organs, oral cavity.