5hmC-profiles in Puerto Rican Hispanic/Latino men with aggressive prostate cancer
The 5hmC modifications and associated gene expression changes in these six genes could be linked to the highest prostate cancer (PCa)-specific mortality in PR H/L men. In conclusion, our study identified 59 DMGs showing concordant epigenetic and transcriptomic changes in tumor tissues and 111 DMGs showing association with aggressive PCa among PR H/L men. Our findings have significant implications for understanding these key genes' molecular mechanisms, which may drive PCa progression and mortality in this population. This will help in developing potential biomarkers or therapeutic targets for personalized treatment strategies in this high-risk subgroup. Future research will explore how these genes contribute to PCa-specific mortality through molecular analyses, with plans to validate them in a larger validation cohort.
Authors
- Jaime Matta (ORCID: https://orcid.org/0000-0001-6668-9021)
- Yoganand Balagurunathan (ORCID: https://orcid.org/0000-0002-5598-4727)
- Jasreman Dhillon (ORCID: https://orcid.org/0000-0001-6785-3487)
- Anders Berglund (ORCID: https://orcid.org/0000-0002-0393-3530)
- Jarline Encarnación-Medina (ORCID: https://orcid.org/0000-0002-0354-6274)
- Julie Dutil (ORCID: https://orcid.org/0000-0002-0313-6443)
- Gilberto Ruiz-Deyá
- Deepak Kilari (ORCID: https://orcid.org/0000-0002-6999-1901)
- Kosj Yamoah (ORCID: https://orcid.org/0000-0001-9055-3538)
- Carmen Ortíz (ORCID: https://orcid.org/0000-0003-3567-7866)
- Jong Y. Park (ORCID: https://orcid.org/0000-0002-6384-6447)
- Liang Wang (ORCID: https://orcid.org/0000-0002-9364-8572)
- Manishkumar S. Patel
- M. Almubarak
- Hyun Park
Institutions
- Ponce Health Sciences University (PR)
- Medical College of Wisconsin (US)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fonc.2025.1541878
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Moffitt Cancer Center
- National Institutes of Health
- University of California, San Francisco
- National Cancer Institute