Leptin acutely increases hepatic triglyceride secretion in patients with lipodystrophy
Leptin acutely increases hepatic VLDL1-TG secretion in patients with lipodystrophy, likely contributing to metreleptin's body weight-independent anti-steatotic effects. The case report suggests that intact autonomic liver innervation may be required for this action, warranting further research.
Authors
- Peter Wolf (ORCID: https://orcid.org/0000-0001-6779-734X)
- Herbert Stangl (ORCID: https://orcid.org/0000-0002-7288-7320)
- Martin Krššák (ORCID: https://orcid.org/0000-0001-9717-803X)
- Magdalena Bastian
- Barış Akıncı (ORCID: https://orcid.org/0000-0002-8634-4845)
- Carolina Cecchetti
- Florian Frommlet (ORCID: https://orcid.org/0000-0003-4104-1768)
- Jürgen Harreiter (ORCID: https://orcid.org/0000-0003-2508-9403)
- Caterina Pelosini
- Alexandra Kautzky‐Willer (ORCID: https://orcid.org/0000-0002-3520-4105)
- Ferruccio Santini (ORCID: https://orcid.org/0000-0002-1706-0822)
- Sabina Baumgartner‐Parzer (ORCID: https://orcid.org/0000-0002-0928-6119)
- Clemens Fürnsinn (ORCID: https://orcid.org/0000-0001-7168-0013)
- Thomas Scherer (ORCID: https://orcid.org/0000-0003-4980-706X)
- Alessandra Gambineri (ORCID: https://orcid.org/0000-0003-2242-6734)
- Giovanni Ceccarini (ORCID: https://orcid.org/0000-0003-0701-642X)
- Michael Stümvoll (ORCID: https://orcid.org/0000-0001-6225-8240)
- Marianna Beghini (ORCID: https://orcid.org/0000-0001-6161-4004)
- Michael Krebs (ORCID: https://orcid.org/0000-0002-9265-7274)
- Lorenz Pfleger (ORCID: https://orcid.org/0000-0003-1268-9565)
- Matthäus Metz (ORCID: https://orcid.org/0000-0002-8344-9799)
- Christel Tran (ORCID: https://orcid.org/0000-0003-4158-536X)
- Aivar Lõokene (ORCID: https://orcid.org/0000-0002-0157-727X)
- Liliana-Imi Gard
- Silvia Magno (ORCID: https://orcid.org/0000-0002-8705-6554)
- Rodrig Marculescu (ORCID: https://orcid.org/0000-0003-1772-6695)
- Robert Risti (ORCID: https://orcid.org/0000-0001-5623-8235)
- İhsan Turan (ORCID: https://orcid.org/0000-0002-5654-247X)
- Michael A Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Martin Wabitsch (ORCID: https://orcid.org/0000-0001-6795-8430)
- Clemens Baumgartner (ORCID: https://orcid.org/0000-0002-5277-4011)
- Martina Häckl (ORCID: https://orcid.org/0000-0003-3182-788X)
- S. Brandt (ORCID: https://orcid.org/0000-0002-8693-2647)
- Konstanze Miehle (ORCID: https://orcid.org/0000-0002-2311-556X)
Institutions
- Tallinn University of Technology (EE)
- Centre Hospitalier Universitaire Vaudois (CH)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Medical University of Vienna (AT)
- University of Lausanne (CH)
Publication Details
- Journal
- Metabolism
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.metabol.2025.156261
- Citations
- 3
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Chiesi Farmaceutici
- Amryt Pharma
- Austrian Science Fund