Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming
This study reveals a paracrine communication circuit during ductular reaction, in which reactive cholangiocyte-derived ORM2 reprogrammes liver macrophages, participating in a pathogenic remodelling of the immune biliary niche.
Authors
- Hilmar Berger (ORCID: https://orcid.org/0000-0002-6304-4946)
- Yeni Ait Ahmed
- Marlene Kohlhepp (ORCID: https://orcid.org/0000-0002-2828-1663)
- Hanyang Liu (ORCID: https://orcid.org/0000-0002-1035-4895)
- Ludovic Vallier (ORCID: https://orcid.org/0000-0002-3848-2602)
- Adrien Guillot (ORCID: https://orcid.org/0000-0002-6002-9986)
- Milad Rezvani (ORCID: https://orcid.org/0000-0002-9550-8725)
- Bianca Franco Leonardi (ORCID: https://orcid.org/0000-0002-9777-9975)
- Carla Frau (ORCID: https://orcid.org/0000-0002-6297-9803)
- Frank Tacke (ORCID: https://orcid.org/0000-0001-6206-0226)
- Natalia Martagón Calderón
- Natalja Amiridze
- Tian Lan
- Yin Guo (ORCID: https://orcid.org/0009-0006-7139-7385)
Institutions
- Universidade de São Paulo (BR)
- Sichuan University (CN)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- National Cancer Institute (US)
- Max Planck Institute for Molecular Genetics (DE)
- Center for Cancer Research (US)
- State Key Laboratory of Biotherapy
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Gut
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1136/gutjnl-2024-334425
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.60
Funders
- Deutsche Forschungsgemeinschaft
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- National Natural Science Foundation of China
- China Scholarship Council