Pharmacokinetics of cannabidiol, (-)-trans-Δ9-tetrahydrocannabinol, and their oxidative metabolites after intravenous and oral administration of a cannabidiol-dominant full-spectrum hemp product to beagle dogs
Both CBD and Δ<sup>9</sup>-THC were rapidly cleared after IV administration and exhibited extensive volumes of distribution. Comparison of clearance to serum hepatic blood flow estimated the hepatic extraction ratio and extent of first pass metabolism after PO administration, which was confirmed by analyzing the single PO dose pharmacokinetic data. The AUC<sub>0-∞</sub> for 7-OH-CBD after single IV compared to single PO dose was not different, suggesting complete absorption of CBD from the formulation in MCT oil when administered with canned dog food.
Authors
- Susanna E. Kitts-Morgan (ORCID: https://orcid.org/0000-0001-5032-4693)
- Richard A. Sams (ORCID: https://orcid.org/0000-0002-1613-763X)
- William W. Muir
Institutions
- Lincoln Memorial University (US)
- Barber-Nichols (United States) (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fvets.2025.1556975
- Citations
- 5
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 6.97