The mammalian acid chitinase promotes oncogenic properties of thyroid cancer cells through the JAK2/STAT3 pathway
CHIA upregulation promoted the proliferation, migration and invasion of thyroid cancer cells through JAK2/STAT3 signaling pathway activation. Therefore, CHIA could represent a potential new oncoprotein for patients with thyroid cancer.
Authors
- Yingying Zhao (ORCID: https://orcid.org/0000-0002-6566-1841)
- Zhiqiang Yi (ORCID: https://orcid.org/0009-0008-7363-4342)
- Hai Jin (ORCID: https://orcid.org/0000-0003-0430-2834)
- Jiaxing An (ORCID: https://orcid.org/0000-0002-0988-9972)
- Renmin Mu
- Biguang Tuo (ORCID: https://orcid.org/0000-0003-3147-3487)
- Zhengxing Zhou (ORCID: https://orcid.org/0000-0001-8507-3660)
- Zilin Deng
- Taolang Li (ORCID: https://orcid.org/0000-0001-8150-7687)
- Minglin Zhang (ORCID: https://orcid.org/0000-0002-5881-3544)
- Hu Wang
- Xuemei Liu (ORCID: https://orcid.org/0000-0002-3104-4343)
- Zhiyuan Ma (ORCID: https://orcid.org/0000-0002-0750-9307)
- Minqian Shen (ORCID: https://orcid.org/0000-0002-6692-6901)
- Jiaxing Zhu (ORCID: https://orcid.org/0000-0001-6143-5807)
- Chengmin Zhang (ORCID: https://orcid.org/0000-0002-9913-111X)
- Guorong Wen
- Chengli Lu
- Zilai Hu
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1530/etj-24-0311
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Education of Guizhou Province