Chinese Guideline for the Diagnosis and Management of Drug‐Induced Liver Injury in Primary Care (2024)

Drug-induced liver injury (DILI) is a drug-induced disease that not only complicates the treatment of the primary disease but may also lead to acute liver failure or even death in severe cases. Drugs commonly used in primary care, such as anti-infective agents and nonsteroidal anti-inflammatory drugs, are major causes of DILI. In addition, a large elderly population, comorbidities, and combination therapy with multiple drugs increase the risk of DILI in primary care. Therefore, primary care providers should proactively screen and monitor high-risk patients to identify potential DILI timely. Currently, diagnosis of DILI relies on the exclusion of liver diseases of other etiologies. Collection of detailed medical history of the patients and careful exclusion of other potential liver injury of other etiologies are crucial for accurate diagnosis. This guideline, developed based on evidence-based medicine from the latest research, aimed to provide primary care providers with professional guidance on the timely identification of suspected DILI cases and standardized diagnosis and management in clinical practice.

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Publication Details

Journal
Journal of Digestive Diseases
Published
2025-01-01
DOI
https://doi.org/10.1111/1751-2980.13337
Citations
5
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
7.79

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article

Chinese Guideline for the Diagnosis and Management of Drug‐Induced Liver Injury in Primary Care (2024)

Xiaoyun Li, Jun Zhan, Liang‐Hu Qu, Xiao Lin Liu et al.
5 citations
Journal of Digestive Diseases
Drug-Induced Hepatotoxicity and Protection
7.79
article

Chinese Guideline for the Diagnosis and Management of Drug‐Induced Liver Injury in Primary Care (2024)

Xiaoyun Li, Jun Zhan, Liang‐Hu Qu, Xiao Lin Liu, Zhengdong Huang, Yang Zheng, Xiao Lu, Jieting Tang, Ming Shao, Zhong Yang, Jing Miao, Xiao Ming Shen, Ya Yang, Yimin Mao, Qing Ge Zhang, Tao Niu, Zongkai Peng, Qing Niu, Bo Liu, Zhengming Chen, Chen Lin, Sun Wei, Li Hai, Wei Zhong, Yang Dong, Zhonghua Lu, Yong Pu, Wei Zhu, Zhao Jia, Wei Zhao, Chun Guo, Hong wu Wang, Yang Zhi, Jingrun Xue
article en
5 citations

Abstract

Drug-induced liver injury (DILI) is a drug-induced disease that not only complicates the treatment of the primary disease but may also lead to acute liver failure or even death in severe cases. Drugs commonly used in primary care, such as anti-infective agents and nonsteroidal anti-inflammatory drugs, are major causes of DILI. In addition, a large elderly population, comorbidities, and combination therapy with multiple drugs increase the risk of DILI in primary care. Therefore, primary care providers should proactively screen and monitor high-risk patients to identify potential DILI timely. Currently, diagnosis of DILI relies on the exclusion of liver diseases of other etiologies. Collection of detailed medical history of the patients and careful exclusion of other potential liver injury of other etiologies are crucial for accurate diagnosis. This guideline, developed based on evidence-based medicine from the latest research, aimed to provide primary care providers with professional guidance on the timely identification of suspected DILI cases and standardized diagnosis and management in clinical practice.

Journal of Digestive DiseasesVol. 26(1-2)
Qingdao University (CN), Yuncheng University (CN), Hebei Medical University (CN), Fujian Medical University (CN), Sun Yat-sen University (CN), Shanghai Jiao Tong University (CN), Renji Hospital (CN), Wuhan University (CN), Soochow University (CN), Wuhan Dongxihu District People Hospital (CN), Zhangqiu City People's Hospital (CN), Sun Yat-sen Memorial Hospital (CN), Jiangyin People's Hospital (CN), Zhuhai People's Hospital (CN), Tianjin People's Hospital (CN), Xingtai People's Hospital (CN), Mengchao Hepatobiliary Hospital (CN), Affiliated Hospital of Qingdao University (CN), Honghe University (CN), Changshu No.1 People's Hospital (CN), Pudong Medical Center (CN), Shanghai East Hospital (CN), The People's Hospital of LinXia (CN), Fifth Hospital In Wuhan (CN), First Hospital of Jiaxing (CN), Tianjin Hospital (CN), First Affiliated Hospital of University of South China (CN), Taizhou First People's Hospital (CN), Jingzhou Central Hospital (CN), First Affiliated Hospital of Soochow University (CN), Tongji Hospital (CN), Changshu No. 2 People's Hospital, Huazhong University of Science and Technology (CN), University of South China (CN)
National Natural Science Foundation of China, Capital Medical University, Central South University, Jiangnan University, Chongqing Medical University, Sichuan University, Shanghai Jiao Tong University, Nanjing Medical University, China Medical University, Soochow University, Peking Union Medical College Hospital, Shanxi Medical University, Xiamen University, Southern Medical University, Nanfang Hospital, Shanghai University of Traditional Chinese Medicine, Peking Union Medical College, Qingdao University, Hebei Medical University, Fujian Medical University, Chinese People’s Liberation Army, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Xiangya Hospital, Central South University, West China Hospital, Sichuan University, Shengjing Hospital
Openalex Percentile: Top 3%
Drug-Induced Hepatotoxicity and Protection
7.79
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