Opposite regulation of intestinal and intrahepatic CD8 <sup>+</sup> T cells controls alcohol-associated liver disease progression
ALD is associated with loss of duodenal CD8<sup>+</sup> T cells but elevation of intrahepatic CD8<sup>+</sup> T cells, which aggravates and ameliorates ALD, respectively. Restoration of survival and functions of intestinal and intrahepatic CD8<sup>+</sup> T cells may represent a novel therapeutic strategy for ALD patients.
Authors
- Peter Stärkel (ORCID: https://orcid.org/0000-0003-2938-4442)
- Maria A. Parra (ORCID: https://orcid.org/0009-0005-0951-2074)
- George Kunos (ORCID: https://orcid.org/0000-0003-1788-4976)
- Andrew MacGregor Cameron (ORCID: https://orcid.org/0000-0002-5810-2398)
- Brandon Peiffer (ORCID: https://orcid.org/0000-0002-6783-2923)
- Zhaoli Sun (ORCID: https://orcid.org/0000-0002-4272-8046)
- Dechun Feng (ORCID: https://orcid.org/0000-0001-7485-762X)
- Bryan Mackowiak (ORCID: https://orcid.org/0000-0001-9840-2013)
- Bin Gao (ORCID: https://orcid.org/0000-0002-0505-2972)
- Yaojie Fu (ORCID: https://orcid.org/0009-0006-5411-6078)
- Yukun Guan
- Yang Wang (ORCID: https://orcid.org/0000-0003-2804-469X)
- Luca Maccioni (ORCID: https://orcid.org/0009-0000-7580-3340)
- Yuhong Lin (ORCID: https://orcid.org/0009-0000-5267-665X)
- Mariia Kim
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Johns Hopkins University (US)
- George Washington University (US)
- Johns Hopkins Medicine (US)
- de Duve Institute (BE)
- National Institute on Alcohol Abuse and Alcoholism (US)
Publication Details
- Journal
- Gut
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1136/gutjnl-2024-334412
- Citations
- 11
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 16.19
Funders
- National Institute on Alcohol Abuse and Alcoholism