Phase II trial of organ preservation program using short-course radiation and FOLFOXIRI for rectal cancer (SHORT-FOX): Two-Year primary outcome analysis
Short-course radiotherapy with a boost followed by FOLFIXIRI results in OP in one-quarter of patients with high-risk rectal cancer, with poorer response among younger patients and T4 disease. Mid-treatment response may help guide timely decision-making regarding treatment.
Authors
- Pejman Ghanouni
- Gregory M. Heestand (ORCID: https://orcid.org/0000-0002-2255-8377)
- Aaron J. Dawes (ORCID: https://orcid.org/0000-0003-4574-6765)
- Arden M. Morris (ORCID: https://orcid.org/0000-0001-5795-2940)
- Elham Rahimy (ORCID: https://orcid.org/0000-0001-7356-3996)
- Eleanor Brown (ORCID: https://orcid.org/0009-0002-7650-7839)
- Natalie Kirilcuk
- George A. Fisher (ORCID: https://orcid.org/0000-0002-6828-3938)
- T.P. Johnson
- Andrew Shelton
- Sara Richter
- Vipul Sheth (ORCID: https://orcid.org/0000-0001-6130-4276)
- Daniel A. King (ORCID: https://orcid.org/0000-0001-6451-712X)
- Shagufta Shaheen (ORCID: https://orcid.org/0000-0001-8385-1641)
- Thomas Holden
- John V. Gahagan
- Erqi Liu Pollom (ORCID: https://orcid.org/0000-0003-2908-6293)
- Cindy Kin (ORCID: https://orcid.org/0000-0001-8273-9471)
- Daniella Klebaner (ORCID: https://orcid.org/0000-0003-2523-4164)
- Daniel T. Chang (ORCID: https://orcid.org/0000-0003-2760-1554)
- Jeffrey Y. Bien (ORCID: https://orcid.org/0000-0002-3111-5674)
- Lucas K. Vitzthum (ORCID: https://orcid.org/0000-0003-2033-6874)
- Christopher T. Chen (ORCID: https://orcid.org/0000-0001-8911-0203)
Institutions
- Northwell Health (US)
- Kaiser Permanente Santa Clara Medical Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.radonc.2025.110884
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences