Loss of LSD1 ameliorates myocardial infarction by regulating angiogenesis via transcriptional activation of Vegfa
Our research indicates that lowered level of LSD1 in cardiomyocytes enhances VEGF-A paracrine secretion and improves endothelial cell function through cross-talk, ultimately promoting angiogenesis. These findings suggest that targeting LSD1 might be an effective therapeutic approach to protect against MI.
Authors
- Lu You
- Xiangmin Meng (ORCID: https://orcid.org/0000-0002-1667-2632)
- Jinghan Yuan
- Tian Deng
- Qiuyu Pang (ORCID: https://orcid.org/0000-0002-7133-3780)
- Qingshan Yang (ORCID: https://orcid.org/0000-0001-8791-8380)
- Zhenfang Zhou
- Hao Li (ORCID: https://orcid.org/0000-0002-9377-1706)
- Décourt Lv
- Qipu Feng
- Bing‐Mei Zhu
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.lfs.2025.123613
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87