Chalcone-9: a novel inhibitor of the JAK-STAT pathway with potent anti-cancer effects in triple-negative breast cancer cells
Chalcone-9 demonstrates significant anti-cancer activity, particularly against TNBC. By targeting the JAK/STAT pathway and promoting apoptosis, chalcone-9 emerges as a promising therapeutic candidate for aggressive breast cancers.
Authors
- Jie Ohn Sohn
- Eun‐Bi Seo
- Song Hee Lee (ORCID: https://orcid.org/0000-0002-4208-261X)
- Byung‐Hak Kim (ORCID: https://orcid.org/0000-0001-7746-6616)
- Sang‐Kyu Ye (ORCID: https://orcid.org/0000-0001-6102-6413)
- Haeri Lee (ORCID: https://orcid.org/0000-0002-1496-3487)
- Seulki Kim (ORCID: https://orcid.org/0000-0002-0064-9366)
- Yong‐Jin Kwon (ORCID: https://orcid.org/0009-0006-9760-9358)
- Jung-Youl Park
Institutions
- Kyungsung University (KR)
- Seoul National University (KR)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s43440-025-00721-w
- Citations
- 2
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Seoul National University