Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion
The FePTX@CM NPs demonstrated effective pancreas targeting, reduced systemic inflammation especially pro-inflammatory cell recruitment and activation, and minimized tissue damage in SAP mouse models, offering a promising therapeutic strategy for clinical SAP management.
Authors
- Y. Cheng (ORCID: https://orcid.org/0009-0007-4791-0051)
- Xuyang Hou
- Shihe Jiang (ORCID: https://orcid.org/0000-0001-8542-2277)
- Hai Huang (ORCID: https://orcid.org/0000-0002-6928-3198)
- W. Xu
- Beibei Cui
- Junyong Wu (ORCID: https://orcid.org/0000-0001-7697-0394)
- Xuedi Hao (ORCID: https://orcid.org/0000-0003-4394-0564)
- Zuxing Wei
- Kuijie Liu (ORCID: https://orcid.org/0000-0002-9628-6116)
- Pengcheng Sun
- Jun He (ORCID: https://orcid.org/0000-0002-5162-6041)
- Yanwen Zheng (ORCID: https://orcid.org/0000-0003-2345-6249)
- Xiaoyan Qi (ORCID: https://orcid.org/0000-0003-3952-1922)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.jare.2025.04.006
- Citations
- 11
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 22.07
Funders
- Natural Science Foundation of Changzhou City
- Health Commission of Henan Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Science and Technology Program of Hunan Province