Prognostic impact of combined loss of RB1, p53 and p21 in muscle-invasive bladder cancer
RB1, p53, and p21 are insufficient as single prognostic markers in MIBC but demonstrate significant prognostic relevance when analyzed in combination. These findings underscore the need for multi-marker approaches in prognostic modeling and personalized treatment strategies for MIBC.
Authors
- Gerald Bastian Schulz (ORCID: https://orcid.org/0000-0002-0340-0304)
- Lennert Eismann (ORCID: https://orcid.org/0000-0002-9971-4411)
- Marie‐Lisa Eich (ORCID: https://orcid.org/0000-0002-8601-4598)
- Michael Chaloupka (ORCID: https://orcid.org/0000-0002-8814-6412)
- Yannic Volz (ORCID: https://orcid.org/0000-0002-5468-9398)
- Benedikt Ebner (ORCID: https://orcid.org/0000-0003-2126-7305)
- Julian Hermans
- Philipp Weinhold (ORCID: https://orcid.org/0000-0002-9144-9289)
- Simon Schallenberg (ORCID: https://orcid.org/0000-0002-7897-7116)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- David Horst (ORCID: https://orcid.org/0000-0003-4755-5743)
- Alexander Büchner (ORCID: https://orcid.org/0000-0001-7895-7070)
- Marc Anwar Kidess (ORCID: https://orcid.org/0009-0005-2072-5521)
- Marie Semmler (ORCID: https://orcid.org/0009-0003-5634-3627)
- Nikolaos Pyrgidis
Institutions
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- University Hospital Cologne (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Pathology - Research and Practice
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.prp.2025.155960
- Citations
- 2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.01