Early fungal colonization and infection as an independent predictor of in-hospital mortality in mechanically ventilated COVID-19 patients: A nationwide target trial emulation study in Taiwan
"Early" fungal colonization and infection within 10 days of corticosteroid initiation is an independent risk factor for in-hospital mortality in mechanically ventilated COVID-19 patients. Future research should explore early intervention strategies, including antifungal prophylaxis, optimized corticosteroid dosing, and immune modulation, to improve survival outcomes.
Authors
- Ming‐Huang Chiu
- Chiao-Hung Wang
- Wei‐Lun Liu (ORCID: https://orcid.org/0000-0001-8593-8492)
- Tse-Bin Yang
- Chung‐Kan Peng (ORCID: https://orcid.org/0000-0001-5696-2557)
- Lun-Yu Jao
- Wei‐Chih Chen (ORCID: https://orcid.org/0000-0003-4172-5529)
- Kuang‐Yao Yang (ORCID: https://orcid.org/0000-0002-2803-980X)
- Hsing-Chun Chen
- Chien‐Hua Tseng (ORCID: https://orcid.org/0000-0001-7020-1180)
- Chih‐Hao Shen (ORCID: https://orcid.org/0000-0002-3910-1269)
- Wen‐Lin Su (ORCID: https://orcid.org/0000-0002-9065-2058)
- Wen‐Feng Fang (ORCID: https://orcid.org/0000-0003-0350-9059)
- Yu-San Chien (ORCID: https://orcid.org/0000-0001-8186-2558)
- Tzu-Tao Chen
- Li‐Kuo Kuo (ORCID: https://orcid.org/0000-0002-2560-8480)
- Shih‐Chieh Chang (ORCID: https://orcid.org/0000-0002-5481-9877)
- Li‐Ta Keng (ORCID: https://orcid.org/0000-0003-2772-8037)
- Thomas Tao-Min Huang
- Chung-Shu Lee (ORCID: https://orcid.org/0000-0003-0466-7796)
- Chi‐Won Suk (ORCID: https://orcid.org/0000-0003-4967-165X)
- Hsueh-Wen Chung
- Tzu-Hsuan Chiu
- Shih‐Chi Ku (ORCID: https://orcid.org/0000-0002-4123-0967)
- Huang-Pin Wu
- Chieh-Jen Wang (ORCID: https://orcid.org/0000-0002-2114-0294)
- Yi‐Ting Chen (ORCID: https://orcid.org/0000-0002-0063-4965)
- Hou-Tai Chang
- Chen‐Chun Lin
- Ming-Cheng Chan
- Chia‐Hao Chang
- Chin‐Ming Chen (ORCID: https://orcid.org/0000-0002-7183-0787)
- Yi-Chun Lai (ORCID: https://orcid.org/0000-0002-4673-7492)
- Chieh‐Mo Lin (ORCID: https://orcid.org/0000-0002-7811-6578)
- Yao-Kuang Wu
- Kuo-Chin Kao
- Chia-Mo Lin
Institutions
- Fu Jen Catholic University (TW)
- Tri-Service General Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
- National Chung Hsing University (TW)
- Chang Gung University (TW)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Taipei Medical University Hospital (TW)
- Mackay Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- Taipei Municipal YangMing Hospital (TW)
- Mackay Medical University (TW)
- National Yang Ming University Hospital (TW)
- Taichung Veterans General Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- Keelung Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Taipei City Hospital (TW)
- Hualien Tzu Chi Medical Center (TW)
- Cathay General Hospital (TW)
- National Taiwan University Hospital (TW)
- Chi Mei Medical Center (TW)
- Wan Fang Hospital (TW)
- Buddhist Tzu Chi Medical Foundation (US)
- Chiayi Chang Gung Memorial Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Memorial Hospital (US)
- Taipei Medical University (TW)
- Yuan Ze University (TW)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.jiph.2025.102767
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Buddhist Tzu Chi Medical Foundation
- Taipei Tzu Chi Hospital