Neuro-immune-cancer interactions: Mechanisms and therapeutic implications for tumor modulation

The interplay between neurons, the immune system, and cancer is a critical area of research with significant therapeutic potential. Neurons regulate immune responses and directly influence tumor progression through neurotransmitters, neurotrophic factors, and synaptic interactions with tumor cells. The peripheral nervous system modulates immune cell activity and inflammation, while the central nervous system coordinates systemic immune responses, influencing tumor growth and metastasis. This neuro-immune-tumor crosstalk is particularly important in peripheral tumors, where local neuroimmune regulation plays a pivotal role. Emerging neuromodulatory therapies, such as Vagus Nerve Stimulation (VNS), offer promising strategies to modulate these interactions. Despite these advances, challenges remain in optimizing neuromodulation and understanding the molecular mechanisms underlying these complex interactions. This perspective highlights the potential for targeting neuro-immune-cancer pathways, with a focus on personalized and precise therapies to address tumor heterogeneity and improve treatment outcomes.