Anticipatory reaching motor behavior characterizes patients within the Alzheimer’s disease continuum in a virtual reality environment
This study highlights significant impairments of reaching movements in AD patients, particularly in terms of anticipatory behavior and success rates. The observed deficits suggest that kinematic metrics could serve as early biomarkers for diagnosis and intervention. These findings emphasize the importance of combining cognitive and sensorimotor assessments for the early detection of AD-related motor dysfunctions. Additionally, they highlight the potential of VR-based motor rehabilitation as a promising approach to address sensorimotor deficits in the AD continuum, improving both motor and cognitive outcomes.
Authors
- Francesco Lacquaniti (ORCID: https://orcid.org/0000-0003-0896-7315)
- Francesco Di Lorenzo (ORCID: https://orcid.org/0000-0003-4588-4041)
- Denise Berger (ORCID: https://orcid.org/0000-0002-4416-3659)
- Martina Assogna (ORCID: https://orcid.org/0000-0002-8588-1112)
- Silvia Conforto (ORCID: https://orcid.org/0000-0001-7323-5220)
- Daniele Bibbo (ORCID: https://orcid.org/0000-0003-1341-5427)
- Ilaria Borghi (ORCID: https://orcid.org/0000-0002-3058-3337)
- Antonella Maselli (ORCID: https://orcid.org/0000-0002-0564-3174)
- Marta Russo (ORCID: https://orcid.org/0000-0003-1020-7542)
- Giacomo Koch (ORCID: https://orcid.org/0000-0001-6155-9439)
- Andrea Casarotto
- Alessia Nobile (ORCID: https://orcid.org/0009-0001-7220-5238)
- Paolo De Pasquale (ORCID: https://orcid.org/0000-0003-1688-2151)
- Andrea d’Avella (ORCID: https://orcid.org/0000-0002-3393-4956)
- Elena Savastano
Institutions
- University of Messina (IT)
- University of Rome Tor Vergata (IT)
- Roma Tre University (IT)
- University of Ferrara (IT)
- IRCCS San Camillo Hospital (IT)
- Center for Translational Neurophysiology of Speech and Communication (IT)
- Nini Hospital (LB)
- Fondazione Santa Lucia (IT)
- Carlo Forlanini Hospital (IT)
- Institute of Cognitive Sciences and Technologies (IT)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s13195-025-01726-6
- Citations
- 1
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- European Commission
- Ministero della Salute
- Horizon 2020 Framework Programme