Fluoropyrimidine Chemotherapy and the Risk of Death and Cardiovascular Events in Patients With Gastrointestinal Cancer
The markedly improved overall survival with fluoropyrimidines in patients with gastrointestinal cancer significantly outweighs the small risk of cardiac arrhythmia and arrest. Oncologists should take this into consideration for decision making to avoid undue clinical conservatism, particularly in patients with cardiovascular disease.
Authors
- Pinkie Chambers (ORCID: https://orcid.org/0000-0002-6669-9411)
- Paul C. Lambert (ORCID: https://orcid.org/0000-0002-5337-663X)
- Sally Vernon (ORCID: https://orcid.org/0009-0007-6290-715X)
- Mark J. Rutherford (ORCID: https://orcid.org/0000-0003-1557-6697)
- Catherine Welch (ORCID: https://orcid.org/0000-0002-6687-964X)
- Kai‐Keen Shiu (ORCID: https://orcid.org/0000-0001-6202-9640)
- Chengsheng Ju (ORCID: https://orcid.org/0000-0001-7860-6262)
- Aderonke Abiodun (ORCID: https://orcid.org/0000-0002-2304-3551)
- Charlotte Manisty (ORCID: https://orcid.org/0000-0003-0245-7090)
- Lizz Paley (ORCID: https://orcid.org/0000-0002-3879-5377)
- Mark de Belder (ORCID: https://orcid.org/0000-0003-2690-8319)
- David Adlam (ORCID: https://orcid.org/0000-0002-0080-9884)
- Jennifer Lai (ORCID: https://orcid.org/0000-0002-0593-1424)
- Freya Tyrer (ORCID: https://orcid.org/0000-0003-2877-4342)
- Wei Li (ORCID: https://orcid.org/0000-0003-1144-518X)
- John Deanfield
- Sarah Slater
- Michael Peake
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University of Leicester (GB)
- Barts Health NHS Trust (GB)
- Glenfield Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
- NHS Digital (GB)
- National Cancer Registration Service (GB)
- NIHR Research Delivery Network (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- University College London (GB)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.jaccao.2025.01.019
- Citations
- 6
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 9.11