Fluoropyrimidine Chemotherapy and the Risk of Death and Cardiovascular Events in Patients With Gastrointestinal Cancer

The markedly improved overall survival with fluoropyrimidines in patients with gastrointestinal cancer significantly outweighs the small risk of cardiac arrhythmia and arrest. Oncologists should take this into consideration for decision making to avoid undue clinical conservatism, particularly in patients with cardiovascular disease.

Authors

Institutions

Publication Details

Journal
JACC CardioOncology
Published
2025-04-08
DOI
https://doi.org/10.1016/j.jaccao.2025.01.019
Citations
6
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
Field-Weighted Citation Impact
9.11
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Fluoropyrimidine Chemotherapy and the Risk of Death and Cardiovascular Events in Patients With Gastrointestinal Cancer

Pinkie Chambers, Paul C. Lambert, Sally Vernon, Mark J. Rutherford et al.
6 citations
JACC CardioOncology
Gastric Cancer Management and Outcomes
9.11
article

Fluoropyrimidine Chemotherapy and the Risk of Death and Cardiovascular Events in Patients With Gastrointestinal Cancer

Pinkie Chambers, Paul C. Lambert, Sally Vernon, Mark J. Rutherford, Catherine Welch, Kai‐Keen Shiu, Chengsheng Ju, Aderonke Abiodun, Charlotte Manisty, Lizz Paley, Mark de Belder, David Adlam, Jennifer Lai, Freya Tyrer, Wei Li, John Deanfield, Sarah Slater, Michael Peake
article en
6 citations

Abstract

The markedly improved overall survival with fluoropyrimidines in patients with gastrointestinal cancer significantly outweighs the small risk of cardiac arrhythmia and arrest. Oncologists should take this into consideration for decision making to avoid undue clinical conservatism, particularly in patients with cardiovascular disease.

JACC CardioOncologyVol. 7(4)
University College London Hospitals NHS Foundation Trust (GB), University of Leicester (GB), Barts Health NHS Trust (GB), Glenfield Hospital (GB), University Hospitals of Leicester NHS Trust (GB), NIHR Leicester Cardiovascular Biomedical Research Unit (GB), NHS Digital (GB), National Cancer Registration Service (GB), NIHR Research Delivery Network (GB), NIHR Leicester Biomedical Research Centre (GB), University College London (GB)
Good health and well-being
Openalex Percentile: Top 2%
Gastric Cancer Management and Outcomes
9.11
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.