Multistate Modeling for Determining Transition Probabilities in Sleep Apnea Severity Across Multiple Nights of Recording

OSA is one of the most frequent chronic diseases associated with a high burden on individuals, health systems, and society. In recent years, the internight variability in OSA severity has emerged as a highly intriguing subject in sleep medicine. It was considered primarily as an obstacle to certainty in clinical decision-making because substantial variability is associated with misdiagnosis (20%-60% on any given night) and potentially incorrect treatment indications.1 Repeated assessments have been proposed as a solution to mitigate the risk of errors.