METTL16-dependent miR-146b-5p m6A modification remodeling sensitize NSCLC to osimertinib via activating PI3K/AKT signaling
In summary, we found that METTL16 mediated miR-146b-5p m6A modification promoted the proliferation and osimertinib resistance of NSLCL by activating PI3K/AKT signaling pathway. Our study is expected to provide a novel insight and potential therapeutic target for NSCLC osimertinib resistance.
Authors
- Hongyang Sang (ORCID: https://orcid.org/0000-0002-4888-5528)
- Jinlong Liu (ORCID: https://orcid.org/0000-0001-6248-9663)
- Xifang Chen (ORCID: https://orcid.org/0000-0002-2734-2583)
- Yingou Zeng
Institutions
- Shanghai University of Medicine and Health Sciences (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12885-025-14041-y
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University