Impact of mesenchymal stromal/stem cell infusions on circulating inflammatory biomarkers in COVID-19 patients: analysis of a phase I-IIa trial
MSC in COVID-19 patients resulted safe and feasible, effectively modulating inflammatory cytokines, in particular mitigating brain damage related biomarker, suggesting both reduced inflammation and a potential neurological protection.
Authors
- Giulia Bruzzi (ORCID: https://orcid.org/0000-0002-5702-0390)
- Tommaso Zoerle (ORCID: https://orcid.org/0000-0001-8713-8085)
- Elisa Pettorelli
- Linda Manicardi
- Giorgio Mari
- Elisa R. Zanier (ORCID: https://orcid.org/0000-0002-3011-8718)
- Francesca Elice (ORCID: https://orcid.org/0000-0002-5176-0064)
- Laura Pasetto (ORCID: https://orcid.org/0000-0003-0319-4448)
- Filomena Pierri (ORCID: https://orcid.org/0000-0002-0005-4127)
- Enrico Clini (ORCID: https://orcid.org/0000-0002-1515-5094)
- Giuseppe Astori (ORCID: https://orcid.org/0000-0003-2794-5218)
- Franco Bambi (ORCID: https://orcid.org/0000-0002-1945-8324)
- Erica Dander
- Maria Cristina Baschieri
- Ilaria Lisi (ORCID: https://orcid.org/0000-0002-4699-4341)
- Valentina Ruggieri
- Massimo Dominici (ORCID: https://orcid.org/0000-0002-4007-1503)
- Carlotta Spano
- Olivia Candini (ORCID: https://orcid.org/0000-0002-5749-9100)
- Daniela Catanzaro (ORCID: https://orcid.org/0000-0003-0765-3058)
- Lorenza Lazzari (ORCID: https://orcid.org/0000-0002-9434-4538)
- Roberto Tonelli (ORCID: https://orcid.org/0000-0002-6202-0758)
- Valentina Bonetto (ORCID: https://orcid.org/0000-0003-0456-2054)
- Anna Merlo (ORCID: https://orcid.org/0000-0002-2741-9624)
- Rachele Ciccocioppo (ORCID: https://orcid.org/0000-0002-6297-7576)
- Giulia Grisendi (ORCID: https://orcid.org/0000-0002-0120-6129)
- M. Bernardi (ORCID: https://orcid.org/0000-0002-2928-2895)
- Stefania Cerri (ORCID: https://orcid.org/0000-0003-4612-1580)
- Giovanni Nattino (ORCID: https://orcid.org/0000-0002-3034-6251)
- Pasquale Mighali (ORCID: https://orcid.org/0000-0003-1440-7672)
- Anna Valeria Samarelli
- Francesca Pischiutta (ORCID: https://orcid.org/0000-0002-7151-0812)
- Giovanna D’Amico (ORCID: https://orcid.org/0000-0001-7809-7269)
- Michela Maur
- Simona Guidi
- Fabiola Signorini (ORCID: https://orcid.org/0009-0001-7147-9704)
- Laura Fiammenghi
- Laura Boschi
- Giorgia De Berardis
Institutions
- University of Verona (IT)
- University of Modena and Reggio Emilia (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- ProQR Therapeutics (Netherlands) (NL)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Meyer Children's Hospital (IT)
- Ospedale Santa Maria (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Ospedale di Mirano (IT)
- Hesperia Hospital (IT)
- Ospedale San Bortolo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Center for Outcomes Research and Clinical Epidemiology (IT)
Publication Details
- Journal
- Cytotherapy
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.jcyt.2025.04.059
- Citations
- 1
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 1.39