Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged <5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort
The low sensitivity of Ultra on double swabs precludes its role as a principal diagnostic approach in young children. However, detection of tuberculosis in children who were not otherwise microbiologically diagnosed suggests the utility of oral swabs as add-on samples to increase yield.
Authors
- Hendrik Simon Schaaf (ORCID: https://orcid.org/0000-0001-5755-4133)
- Nisreen Khambati (ORCID: https://orcid.org/0000-0003-2693-3266)
- Abner Tagoola
- R Post
- Adeodata Kekitiinwa (ORCID: https://orcid.org/0000-0001-8240-1796)
- Gloria Ninsiima
- Sharley Melissa Aloyo (ORCID: https://orcid.org/0000-0002-0382-7164)
- Rose Magala
- Grace P. Kisitu
- Eric Bugumirwa
- Ann Tufariello
- Hellen Nassolo
- Mary Nakagwa
- Benedicto Mugabi
- Rogers Kamulegeya (ORCID: https://orcid.org/0000-0001-7972-3647)
- Allen Nabisere (ORCID: https://orcid.org/0009-0003-9397-6351)
- Derek T. Armstrong (ORCID: https://orcid.org/0000-0001-6223-4839)
- Willy Ssengooba (ORCID: https://orcid.org/0000-0002-1643-110X)
- Francesca Wanda Basile
- Agnes Turyamubona (ORCID: https://orcid.org/0000-0001-7183-9303)
- Nathan J. Mudrak (ORCID: https://orcid.org/0000-0001-7853-4641)
- Rose Chalo Nabirye
- Margaretha de Vos (ORCID: https://orcid.org/0000-0003-3059-2986)
- Grace Miriam Ahimbisibwe (ORCID: https://orcid.org/0000-0001-9015-3147)
- Morten Rühwald (ORCID: https://orcid.org/0000-0002-1597-441X)
- Emmanuel Nasinghe (ORCID: https://orcid.org/0000-0002-2797-3596)
- Else M. Bijker (ORCID: https://orcid.org/0000-0002-2367-5874)
- John Paul Lubega
- Kiranjot Arora
- Emily Douglass (ORCID: https://orcid.org/0000-0002-9141-6057)
- David Alland (ORCID: https://orcid.org/0000-0001-5196-1571)
- Moses Lutaakome Joloba (ORCID: https://orcid.org/0000-0002-0334-9983)
- Prossy Mbekeeka
- David L. Hom (ORCID: https://orcid.org/0009-0003-0778-2076)
- Germine Nakayita
- Angella N. Mirembe
- Jerrold J. Ellner (ORCID: https://orcid.org/0000-0001-6150-0082)
- Lydia Nakiyingi (ORCID: https://orcid.org/0000-0001-7263-3198)
- Megan Palmer (ORCID: https://orcid.org/0000-0002-2534-2483)
- Adam Penn‐Nicholson (ORCID: https://orcid.org/0000-0002-1883-0059)
- Eric Wobudeya (ORCID: https://orcid.org/0000-0001-9574-5539)
- Khaver Bashir
- Gerald Agaba Muzorah
- Soyeon Kim (ORCID: https://orcid.org/0000-0002-4776-6092)
- Jessica Tagobera
- Samuel Kasibante
- Florence Kalembe
- Brenda Sharon Nakalanda
- Ravi Prakash Upadhyay (ORCID: https://orcid.org/0000-0002-1027-8992)
- Israel Odongo
- Rinn Song
- Susan E. Dorman (ORCID: https://orcid.org/0000-0001-6882-9470)
- Henry Balwa
- Sandra Ruth Babirye (ORCID: https://orcid.org/0009-0004-7773-7008)
- April Borkman
- Rudie Desravines
- Stephannie Nabuduwa
- Farag Kakyama Luwambya
- Malik Koire
- Kanyange Angel Moureen
- Sheillah Ansiima
- George Haumba
- Florence Kalawa
- Nakitto Aisha Kawwoya
- Daisy Kyamulabi
- Frank Matovu
- Nelson Muhumuza
- Levi Mwanga
- Aminah Nakyazze
- Rose Namaganda
- Claire Night
Institutions
- Rutgers, The State University of New Jersey (US)
- FIND (CH)
- Desmond Tutu HIV Foundation (ZA)
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- Stellenbosch University (ZA)
- Maastricht University Medical Centre (NL)
- Mulago Hospital (UG)
- Jinja Hospital (UG)
- University of Oxford (GB)
- Baylor College of Medicine Children’s Foundation (UG)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Makerere University (UG)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1093/ofid/ofaf206
- Citations
- 3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.19