Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions
In conclusion, we found that the release of interferon-β after radiation increases with the radiation dose up to 20 Gy and that carbon ions have the potential to elicit a strong innate immune signaling.
Authors
- Burkhard Jakob (ORCID: https://orcid.org/0000-0003-2404-377X)
- Maik Schork
- Nicole Averbeck (ORCID: https://orcid.org/0000-0001-6752-6670)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Claudia Fournier (ORCID: https://orcid.org/0000-0002-1007-9934)
- Cristina Totis
- Gaia Volpi
- Dennis F Hintze
- Alexander Helm
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- University of Pavia (IT)
- Technische Universität Darmstadt (DE)
- Federico II University Hospital (IT)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.adro.2025.101783
- Citations
- 6
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Erasmus+