Evaluation of Some metabolic products before and after hemodialysis in chronic renal failure patients in Misurata, Libya

Chronic renal failure is a gradual loss of kidney function leading to accumulation of urea, creatinine and other waste products in the blood. The current study was designed to measure the efficiency of dialysis in patients with chronic renal failure, by evaluating some metabolic products before and after hemodialysis. 60 samples of renal failure patients (30 males and 30 females) aged 14-70 years were taken from dialysis centres in Misurata city (Libya). The samples were divided based on the age of the patients into 4 age groups, and the results obtained were compared with the control group (30 individuals). The results of the study showed that the levels of urea, creatinine, uric acid and phosphorus were high before the dialysis process and decreased significantly after dialysis with a statistical significance of P-value < 0.05. When compared to the control group, the results were close to the normal level with a statistical significance of P-value < 0.05. The levels of urea, creatinine, uric acid and phosphorus were higher in males than females before and after dialysis. Calcium levels in females were slightly higher than males. The age group (14-27) recorded the lowest levels of creatinine, uric acid and phosphorus, while the age group (42-55) recorded the lowest levels of urea and the group between 14-27 recorded the highest levels of calcium after dialysis. The study concluded that hemodialysis increases the level of calcium and reduces the level of urea, creatinine, uric acid and phosphorus in the blood serum. The study recommends evaluating more comprehensive criteria for kidney failure and studying the disease from a genetic perspective. Key words: Hemodialysis, metabolic products, chronic renal failure, Libya.