Identification of DNA damage and repair gene-related markers in pancreatic ductal adenocarcinoma by single-cell and bulk RNA sequencing
Our creative integration of bulk RNA sequencing and scRNA-seq data allowed us to construct a DDR-related prognostic model. Our model can be used to predict the immunological features, treatment response and prognosis of PDAC with a relatively high degree of accuracy.
Authors
- Jin Xu (ORCID: https://orcid.org/0000-0002-2942-8604)
- Jianhui Yang (ORCID: https://orcid.org/0000-0002-8710-1722)
- Chao-Yi Zhang
- Xianjun Yu (ORCID: https://orcid.org/0000-0002-6697-7143)
- Wei Wang (ORCID: https://orcid.org/0000-0001-5850-9107)
- Rong Tang (ORCID: https://orcid.org/0000-0001-7468-8424)
- Cong Zhou (ORCID: https://orcid.org/0009-0008-4582-4122)
- Yueyue Chen
- Yangyi Li (ORCID: https://orcid.org/0009-0008-6564-1710)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1007/s12672-025-02293-w
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China