Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
AOH1996 safely and effectively targets TRCs in preclinical PDAC models, with initial clinical evidence supporting its potential for treating chemotherapy-refractory PDAC. Further clinical development is warranted.
Authors
- Robert J. Hickey (ORCID: https://orcid.org/0000-0001-5099-8137)
- Caroline M. Li (ORCID: https://orcid.org/0000-0003-4091-3392)
- Vincent Chung (ORCID: https://orcid.org/0000-0001-9475-808X)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Shanna J. Smith
- Laleh Golkar Melstrom (ORCID: https://orcid.org/0000-0001-6279-7981)
- Linda H. Malkas
- Min Li (ORCID: https://orcid.org/0000-0003-1330-2326)
- Vishwas Parekh (ORCID: https://orcid.org/0000-0003-3131-2958)
- Robert Lingeman (ORCID: https://orcid.org/0000-0003-2737-1533)
- Syed Rahmanuddin (ORCID: https://orcid.org/0000-0003-2507-8755)
- Mustafa Raoof (ORCID: https://orcid.org/0000-0003-4710-2226)
- Thuy Phan
- Fan Meng
- Galyah Boneh
- Yilun Liu (ORCID: https://orcid.org/0000-0001-6884-8487)
- Haiqing Li (ORCID: https://orcid.org/0000-0001-5583-2240)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0002-1618-4006)
Institutions
- City Of Hope National Medical Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- City of Hope (US)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Beckman Research Institute
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1053/j.gastro.2025.02.038
- Citations
- 7
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- American Cancer Society
- Pancreatic Cancer Action Network
- National Comprehensive Cancer Network
- National Institutes of Health
- National Cancer Institute