Enantioselective Synthesis of 2-Aryl-3,3-Disubstituted Indolines from 3<i>H</i>-Indoles via Deracemization
An enantioselective synthesis of 2-aryl 3,3-disubstituted 3<i>H</i>-indoles has been successfully developed via a deracemization process involving borane-catalyzed hydrogenation and chiral phosphoric-acid-catalyzed asymmetric transfer hydrogenation. A variety of 3<i>H</i>-indoles were effective substrates to afford the desired indolines in 86-95% yields with 45-92% ee's.
Authors
- Guangyu Cui (ORCID: https://orcid.org/0000-0002-7013-5459)
- Zaiqi Han (ORCID: https://orcid.org/0000-0003-4697-9712)
- Xiangqing Feng (ORCID: https://orcid.org/0000-0003-1739-925X)
- Haifeng Du (ORCID: https://orcid.org/0000-0003-0122-3735)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1021/acs.joc.5c00100
- Citations
- 2
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China