Oil palm Phenolics supplementation improves plasma antioxidant levels and modulates inflammatory markers in individuals with minor Hyperlipidaemia: A randomized, double-blind, placebo-controlled trial

Oil palm phenolics (OPP), an aqueous byproduct of palm oil milling, contains phenolic compounds with potential medicinal properties, including cardioprotective effects. OPP has been shown to be safe and well-tolerated in human studies. Preclinical research has highlighted its antioxidant and anti-inflammatory properties, as well as its role in reducing cholesterol levels. This study evaluated the effects of OPP supplementation on antioxidant enzyme activity and inflammatory markers in individuals with minor hyperlipidaemia. In a 60-day parallel, placebo-controlled, randomized trial, 50 participants were assigned to receive either a placebo or 250 mg OPP daily. Physical examinations and fasting blood samples were conducted on Days 1, 30, and 60. Compared to placebo, OPP significantly increased total antioxidant capacity ( p = 0.001) and enhanced antioxidant parameters (T-AOC, GSH-Px, GR, T-SOD). Additionally, OPP supplementation reduced TNF-α levels on Day 60. These findings suggest that OPP enhances antioxidant defense and reduces inflammation in minor hyperlipidaemia, warranting further investigation. • Oil Palm Phenolics (OPP) enhances total antioxidant capacity in individuals with hyperlipidemia. • OPP supplementation significantly reduces TNF-α levels, modulating inflammation. • OPP is safe for human consumption with no adverse effects observed in a 60-day trial. • Findings suggest OPP as a promising nutraceutical for cardiovascular health improvement.