Revolutionary 3D-Printed manganese silicate Bioceramic scaffolds: A new frontier in bone tissue engineering

As the application of 3D printing technology in the biomedical field continues to expand, in-depth research into its potential is becoming crucial for future advancements. This study utilized manganese-doped strontium magnesium silicate powder (Ca 2 MgSi 2 O 7 ) to fabricate porous 3D-printed scaffolds, aiming to investigate the effect of varying manganese doping concentrations on bone defect repair. The results demonstrated that these scaffolds possess excellent biodegradability, mechanical properties, and biocompatibility. Both in vitro and in vivo experiments indicated that scaffolds with low concentrations of manganese doping significantly enhance osteoblast activity and effectively support bone defect repair. Although high concentrations of manganese doping showed some inhibitory effects on osteoblast proliferation, they still positively impacted bone defect repair. The development of manganese-doped strontium-magnesium whitlockite scaffolds, which uniquely integrate biodegradability, osteoinductivity, and mechanical stability, surpassing conventional scaffolds. This study not only demonstrates superior bioactivity compared to existing biomaterials but also provides a paradigm shift in bioactive scaffold engineering. This work provides a new research direction for the development of bone defect repair materials.