APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion
This study reveals that APOE regulates ferroptosis through the PI3K/AKT1 pathway, thereby driving macrophage polarization toward the M2 phenotype, which in turn promotes the invasion and migration of PTC.
Authors
- Bin Yu (ORCID: https://orcid.org/0000-0001-8795-4592)
- Min Li (ORCID: https://orcid.org/0000-0001-6902-7242)
- Song Zuo (ORCID: https://orcid.org/0000-0002-8278-1802)
- Ziwen Li (ORCID: https://orcid.org/0009-0006-4832-3871)
- Jiayin Song (ORCID: https://orcid.org/0009-0003-7741-5685)
- Gang Xue (ORCID: https://orcid.org/0000-0002-3776-0009)
- Jingfang Wu
- Xu Lin (ORCID: https://orcid.org/0000-0002-3118-053X)
- Sinuo Sun
- Ronghua Huo
Institutions
- Hebei North University (CN)
- Zhangjiakou Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.imbio.2025.152900
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04