Blockade of calcium-activated chloride channel ANO1 ameliorates ionizing radiation-induced intestinal injury
These findings suggest that targeting ANO1 not only alleviates radiation-induced intestinal injury in mice but also enhances CRC radiosensitivity. Thus, ANO1 represents a promising therapeutic target for mitigating the side effects of RT in CRC patients.
Authors
- Yuna Wang
- Tong Yuan (ORCID: https://orcid.org/0009-0009-6463-6220)
- Yuying Guo
- Saijun Fan (ORCID: https://orcid.org/0000-0003-0691-6864)
- Junling Zhang (ORCID: https://orcid.org/0000-0003-4321-3156)
- Lei Xia (ORCID: https://orcid.org/0000-0003-2671-8347)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.jare.2025.04.009
- Citations
- 1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Chinese Academy of Meteorological Sciences